A driver fled the scene after hitting a pedestrian on the Bicester Road last night, causing serious injuries.
A 34-year old man was rushed to Stoke Mandeville hospital where he remains after being run down at around 10:50pm between Northern Road and Cubitt Street.
Police say the car involved was a white BMW.
Investigating officer PC Tom Walker of the Joint Operations Roads Policing Unit, based at Milton Keynes, said: “I am appealing to anybody who was in the area and witnessed this collision to please make contact with Thames Valley Police, either online or by calling 101, quoting reference number 43210497462.
“I am very keen to hear from anyone who may have been driving in the area at around 10.50pm on Wednesday and have dash-cam in their vehicles to please check this and contact us if it has captured anything that can assist this investigation.
“The driver of the white BMW did not stop at the scene of the collision, and so we are keen to identify this person as a priority.
“For 100% anonymity, you can also call the independent charity Crimestoppers on 0800 555 111.”