Motorists are being advised to avoid the area if possible, while bus services will be disrupted.
There is a lane closure currently in place near The Aristocrat (opposite the bus lay-by). However, Thames Water will need to move into the central lane to locate and fix the leak.
The move will result in the closure of two out of three lanes, only allowing vehicle access straight ahead on the A413 Wendover Road towards the Broad Leys/Esso garage. Vehicles will not be able to turn right towards Stoke Road/ Mandeville Road.
Vehicles travelling from Aylesbury to Stoke Mandeville will be diverted via A413 Wendover Road from 7pm this evening (16/1) and into tomorrow.
Bucks Highways say until such time as Thames Water have located the leak, they are unable to advise when the lane closures will be lifted. They also advise avoiding the area if possible.
As a result, Bus routes 130 and 300 travelling from Aylesbury towards Stoke Mandeville Hospital will need to divert via Oxford Road and Churchill Avenue missing stops on Walton Street, Stoke Road and Mandeville Road.
Bucks Highways have rescheduled planned works on Lower Road, Aylesbury, to alleviate pressure on the network and their technicians will be closely monitoring the situation.
SCAS is supporting the calls made today (24/4) by the Association of Ambulance Chief Executives (AACE) for further national policy interventions to help combat the growing number of violent assaults against ambulance workers in the UK.
They want residents to remember to include those forgotton about items in your recycling collection from home - the ones that can be recycled but are often put in the waste bin.
The initiative by Active in the Community was designed to promote sustainability, accessibility and community engagement through the upcycling of unused bicycles.
Aylesbury is set to come alive on Sunday 27 April, the Sunday after St George's Day, with a vibrant celebration featuring a Myths & Legends Historical Fayre and a Grand Uniformed Parade.
Healthcare charity, the Cancer Care and Haematology Fund (CCHF), has announced funding of more than £60,000 for new equipment to enhance patient care at Buckinghamshire treatment centres.