The road was closed after the collision, which was one of several on Bucks Roads earlier today.
A woman, a man and a girl were all hurt after a crash nr the Weedon junction on the Buckingham Road.
Fire crews attended the scene and released the woman from her care, and left her in the care of South Central Ambulance Service. A girl and a man were also injured but not trapped.
Firefighters used an environmental protection kit to prevent vehicle fluids from entering the water course.
There were further accidents on the A41 Bicester Road near Fleet Marston, and on the A418 through Bierton.
With heavy rain across the county we are being advised to take extra care on our journeys, and watch out for surface and standing water.
For updates and more travel details where you are check out our Travel page